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Interactions between monoamine oxidase A rs1137070 and smoking on brain structure and function in male smokers
Author(s) -
Shen Zhujing,
Huang Peiyu,
Wang Chao,
Qian Wei,
Luo Xiao,
Gu Quanquan,
Chen Huan,
Wang Hongjuan,
Yang Yihong,
Zhang Minming
Publication year - 2019
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14282
Subject(s) - monoamine oxidase a , orbitofrontal cortex , nicotine , monoamine neurotransmitter , prefrontal cortex , psychology , neuroscience , monoamine oxidase , dopamine , dorsolateral prefrontal cortex , inferior parietal lobule , nucleus accumbens , serotonin , medicine , endocrinology , physiology , biology , functional magnetic resonance imaging , cognition , biochemistry , receptor , enzyme
The monoamine oxidase A ( MAOA ) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. However, the underlying neural mechanisms of the gene × environment interactions remain largely unknown. In this study, we aimed to explore the interactive effects of the rs1137070 and cigarette smoking on gray matter volume ( GMV ) and functional connectivity strength ( FCS ). A total of 81 smokers and 42 nonsmokers were enrolled in the present study. Voxel‐based morphometry analysis showed a significant rs1137070 genotype × smoking effect on the GMV of the left orbitofrontal cortex ( OFC ), such that individuals with risk allele had greater GMV among nonsmokers but not smokers. Meanwhile, rs1137070 variant and nicotine dependence interactively altered the FCS of the right hippocampus, the left inferior parietal lobule ( IPL ), the left dorsolateral prefrontal cortex and bilateral OFC . In addition, the FCS in the left IPL was correlated with smoking initiation and smoking years in smokers with the risk allele. These findings suggest that MAOA rs1137070 contributes to the susceptibility to nicotine dependence through its influence on brain circuits involved in reward and attention, and interacts with smoking in the progression.