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Mood‐related central and peripheral clocks
Author(s) -
Ketchesin Kyle D.,
BeckerKrail Darius,
McClung Colleen A.
Publication year - 2020
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.14253
Subject(s) - circadian rhythm , neuroscience , monoaminergic , mood , mood disorders , psychology , population , bipolar disorder , glutamatergic , suprachiasmatic nucleus , dark therapy , light effects on circadian rhythm , chronobiology , biology , cognition , medicine , psychiatry , serotonin , anxiety , genetics , glutamate receptor , receptor , environmental health
Mood disorders, including major depression, bipolar disorder, and seasonal affective disorder, are debilitating disorders that affect a significant portion of the global population. Individuals suffering from mood disorders often show significant disturbances in circadian rhythms and sleep. Moreover, environmental disruptions to circadian rhythms can precipitate or exacerbate mood symptoms in vulnerable individuals. Circadian clocks exist throughout the central nervous system and periphery, where they regulate a wide variety of physiological processes implicated in mood regulation. These processes include monoaminergic and glutamatergic transmission, hypothalamic–pituitary–adrenal axis function, metabolism, and immune function. While there seems to be a clear link between circadian rhythm disruption and mood regulation, the mechanisms that underlie this association remain unclear. This review will touch on the interactions between the circadian system and each of these processes and discuss their potential role in the development of mood disorders. While clinical studies are presented, much of the review will focus on studies in animal models, which are attempting to elucidate the molecular and cellular mechanisms in which circadian genes regulate mood.