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Heterogeneity of retinogeniculate axon arbors
Author(s) -
Hong Y. Kate,
Burr Eliza F.,
Sanes Joshua R.,
Chen Chinfei
Publication year - 2019
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.13986
Subject(s) - neuroscience , axon , biology , retina , thalamus , lateral geniculate nucleus , visual system , retinal ganglion cell , retinal waves , geniculate , synapse , anatomy , giant retinal ganglion cells , nucleus
Abstract The retinogeniculate synapse transmits information from retinal ganglion cells ( RGC ) in the eye to thalamocortical relay neurons in the visual thalamus, the dorsal lateral geniculate nucleus ( dLGN ). Studies in mice have identified genetic markers for distinct classes of RGC s encoding different features of the visual space, facilitating the dissection of RGC subtype‐specific physiology and anatomy. In this study, we examine the morphological properties of axon arbors of the BD ‐ RGC class of ON ‐ OFF direction selective cells that, by definition, exhibit a stereotypic dendritic arbor and termination pattern in the retina. We find that axon arbors from the same class of RGC s exhibit variations in their structure based on their target region of the dLGN . Our findings suggest that target regions may influence the morphologic and synaptic properties of their afferent inputs.