Premium
Serotonin transporter inhibition during neonatal period induces sex‐dependent effects on mitochondrial bioenergetics in the rat brainstem
Author(s) -
Silva Tercya Lucidi Araujo,
Braz Glauber Rudá Feitoza,
Silva Severina Cassia de Andrade,
Pedroza Anderson Apolônio da Silva,
Freitas Cristiane de Moura,
Ferreira Diorginis José Soares,
da Silva Aline Isabel,
Lagranha Claudia Jacques
Publication year - 2018
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.13971
Subject(s) - fluoxetine , serotonin reuptake inhibitor , serotonin , serotonin transporter , endocrinology , medicine , bioenergetics , brainstem , raphe nuclei , biology , lactation , period (music) , reuptake , mitochondrion , serotonergic , pregnancy , receptor , microbiology and biotechnology , genetics , physics , acoustics
The serotonin reuptake is mainly regulated by the serotonin transporters ( SERT s), which are abundantly found in the raphe nuclei, located in the brainstem. Previous studies have shown that dysfunction in the SERT has been associated with several disorders, including depression and cardiovascular diseases. In this manuscript, we aimed to investigate how gender and the treatment with a serotonin selective reuptake inhibitor ( SSRI ) could affect mitochondrial bioenergetics and oxidative stress in the brainstem of male and female rats. Fluoxetine, our chosen SSRI , was used during the neonatal period (i.e., from postnatal Day 1 to postnatal Day 21— PND 1 to PND 21) in both male and female animals. Thereafter, experiments were conducted in adult rats (60 days old). Our results demonstrate that, during lactation, fluoxetine treatment modulates the mitochondrial bioenergetics in a sex‐dependent manner, such as improving male mitochondrial function and female antioxidant capacity.