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Different pre‐scanning instructions induce distinct psychological and resting brain states during functional magnetic resonance imaging
Author(s) -
Kawagoe Toshikazu,
Onoda Keiichi,
Yamaguchi Shuhei
Publication year - 2018
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.13787
Subject(s) - functional magnetic resonance imaging , resting state fmri , default mode network , functional connectivity , salience (neuroscience) , psychology , neuroimaging , dynamic functional connectivity , neuroscience , audiology , mental image , brain activity and meditation , brain mapping , cognitive psychology , cognition , medicine , electroencephalography
Resting‐state functional magnetic resonance imaging (rs‐ fMRI ) is widely used to investigate functional brain network connectivity during rest or when the subject is not performing an explicit task. In the standard procedure, subjects are instructed to ‘let your mind wander’ or ‘think of nothing’. While these instructions appear appropriate to induce a ‘resting‐state’, they could induce distinct psychological and physiological states during the scan. In this study, we investigated whether different instructions affect mental state and functional connectivity ( FC ) (i.e. induce distinct ‘resting states’) during rs‐ fMRI scanning. Thirty healthy subjects were subjected to two rs‐ fMRI scans differing only in pre‐scan instructions: think of nothing ( TN ) and mind‐wandering ( MW ) conditions. Self‐reports confirmed that subjects spent the majority of the scanning time in the appropriate mental state. Independent component analysis extracted 19 independent components ( IC s) of interest and functional network connectivity analyses indicated several conditional differences in FC s among those IC s, especially characterised by stronger FC in the MW condition than in the TN condition, between default mode network and salience/visual/frontal network. Complementary correlation analysis indicated that some of the network FC s were significantly correlated with their self‐reported data on how often they had the TN condition during the scans. The present results provide evidence that the pre‐scan instruction has a significant influence on resting‐state FC and its relationship with mental activities.