Premium
Mu opioid receptor signaling in the nucleus accumbens shell increases responsiveness of satiety‐modulated lateral hypothalamus neurons
Author(s) -
Tandon Shashank,
Keefe Kristen A.,
Taha Sharif A.
Publication year - 2017
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.13579
Subject(s) - damgo , nucleus accumbens , endocrinology , medicine , lateral hypothalamus , excitatory postsynaptic potential , μ opioid receptor , stimulation , chemistry , agonist , palatability , opioid , neuroscience , psychology , enkephalin , receptor , food science
Opioid signaling in the nucleus accumbens shell ( sNA cc) has been implicated in hedonic feeding and binge eating behavior. The sNA cc projects to the lateral hypothalamus ( LH ), and this pathway has been suggested to modulate palatability‐driven feeding behavior. In this study, we investigated the effects of sNA cc mu opioid receptor ( MOR ) stimulation on firing rates of LH neurons in previously sated rats. Neural firing in the LH was recorded while food‐deprived rats performed an operant task to obtain sweetened Intralipid (a 4% fat emulsion containing 5% sucrose) before and after bilateral sNA cc infusion of either a MOR agonist [D‐Ala2, N‐MePhe4, Gly‐ol]‐enkephalin ( DAMGO ) or a saline control solution. During sessions in which saline was infused into the sNA cc, the number of trials completed after infusion were significantly lower than the number completed before infusion, likely reflecting animals’ increased satiety state. During sessions in which DAMGO was infused into the sNA cc, the decrease in the number of trials completed (comparing post‐ vs. pre‐infusion trials) was significantly attenuated. Electrophysiological recording showed that the percentage of LH neurons showing an excitatory response due to behavioral events (cue presentation, lever press, lever retraction, and consumption) was reduced in post vs. pre‐saline infusion period. However, the percentage of LH neurons showing excitatory responses to the same behavioral events was similar in pre‐ and post‐ DAMGO infusion periods. These findings suggest that MOR stimulation in sNA cc leads to an increase in stimulus‐evoked excitatory signaling in LH neurons which could contribute to preventing satiety‐induced decline in palatable food intake.