Premium
The role of neurogenesis during development and in the adult brain
Author(s) -
Jin Xing
Publication year - 2016
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.13251
Subject(s) - neurogenesis , neuroscience , neural stem cell , biology , embryonic stem cell , mammalian brain , neural development , psychology , stem cell , microbiology and biotechnology , biochemistry , gene
Neural stem cells ( NSC s) give rise to neurons during development. NSC s persist and neurogenesis continues in restricted regions of postnatal and adult brains. Adult‐born neurons integrate into existing neural circuits by synaptic connections and participate in the regulation of brain function. Thus, understanding NSC s and neurogenesis may be crucial in the development of new strategies for brain repair. Here, we introduce the lineage of NSC s from embryonic to adult stages and summarize recent studies on maturation and integration of adult‐born neurons. We also discuss the regulation and potential functions of adult neurogenesis in physiological and pathological conditions.