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Interaction of synchronized dynamics in cortex and basal ganglia in Parkinson's disease
Author(s) -
Ahn Sungwoo,
Zauber S. Elizabeth,
Worth Robert M.,
Witt Thomas,
Rubchinsky Leonid L.
Publication year - 2015
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12980
Subject(s) - basal ganglia , neuroscience , subthalamic nucleus , local field potential , parkinson's disease , electroencephalography , synchronization (alternating current) , deep brain stimulation , cortex (anatomy) , psychology , beta rhythm , motor cortex , biology , central nervous system , disease , medicine , computer science , stimulation , pathology , computer network , channel (broadcasting)
Parkinson's disease pathophysiology is marked by increased oscillatory and synchronous activity in the beta frequency band in cortical and basal ganglia circuits. This study explores the functional connections between synchronized dynamics of cortical areas and synchronized dynamics of subcortical areas in Parkinson's disease. We simultaneously recorded neuronal units (spikes) and local field potentials ( LFP ) from subthalamic nucleus ( STN ) and electroencephalograms ( EEG s) from the scalp in parkinsonian patients, and analysed the correlation between the time courses of the spike– LFP synchronization and inter‐electrode EEG synchronization. We found the (non‐invasively obtained) time course of the synchrony strength between EEG electrodes and the (invasively obtained) time course of the synchrony between spiking units and LFP in STN to be weakly, but significantly, correlated with each other. This correlation is largest for the bilateral motor EEG synchronization, followed by bilateral frontal EEG synchronization. Our observations suggest that there may be multiple functional modes by which the cortical and basal ganglia circuits interact with each other in Parkinson's disease: not only may synchronization be observed between some areas in cortex and the basal ganglia, but also synchronization within cortex and within basal ganglia may be related, suggesting potentially a more global functional interaction. More coherent dynamics in one brain region may modulate or activate the dynamics of another brain region in a more powerful way, causing correlations between changes in synchrony strength in the two regions.