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Top‐down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb
Author(s) -
KomanoInoue Sayaka,
Manabe Hiroyuki,
Ota Mizuho,
KusumotoYoshida Ikue,
Yokoyama Takeshi K.,
Mori Kensaku,
Yamaguchi Masahiro
Publication year - 2014
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12679
Subject(s) - postprandial , olfactory bulb , olfactory system , sensory system , period (music) , stimulation , chemistry , endocrinology , medicine , odor , agonist , neuroscience , receptor , biology , central nervous system , biochemistry , insulin , physics , acoustics
Elimination of granule cells ( GC s) in the olfactory bulb ( OB ) is not a continual event but is promoted during a short time window in the postprandial period, typically with postprandial sleep. However, the neuronal mechanisms for the enhanced GC elimination during the postprandial period are not understood. Here, we addressed the question of whether top‐down inputs of centrifugal axons from the olfactory cortex ( OC ) during the postprandial period are involved in the enhanced GC elimination in the OB . Electrical stimulation of centrifugal axons from the OC of anesthetized mice increased GC apoptosis. Furthermore, pharmacological suppression of top‐down inputs from the OC to the OB during the postprandial period of freely behaving mice by γ‐aminobutyric acid ( GABA ) A receptor agonist injection in the OC significantly decreased GC apoptosis. Remarkable apoptotic GC elimination in the sensory‐deprived OB was also suppressed by pharmacological blockade of top‐down inputs. These results indicate that top‐down inputs from the OC to the OB during the postprandial period are the crucial signal promoting GC elimination, and suggest that the life and death decision of GC s in the OB is determined by the interplay between bottom‐up sensory inputs from the external world and top‐down inputs from the OC .