Premium
Disrupted in schizophrenia 1 and synaptic function in the mammalian central nervous system
Author(s) -
Randall Andrew D.,
Kurihara Mai,
Brandon Nicholas J.,
Brown Jon T.
Publication year - 2014
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12500
Subject(s) - neuroscience , schizophrenia (object oriented programming) , central nervous system , biology , function (biology) , chromosomal translocation , gene , psychology , genetics , psychiatry
The disrupted in schizophrenia 1 ( DISC 1) gene is found at the breakpoint of an inherited chromosomal translocation, and segregates with major mental illnesses. Its potential role in central nervous system ( CNS ) malfunction has triggered intensive investigation of the biological roles played by DISC 1, with the hope that this may shed new light on the pathobiology of psychiatric disease. Such work has ranged from investigations of animal behavior to detailed molecular‐level analysis of the assemblies that DISC 1 forms with other proteins. Here, we discuss the evidence for a role of DISC 1 in synaptic function in the mammalian CNS .