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Synaptic vesicle protein 2A: basic facts and role in synaptic function
Author(s) -
MendozaTorreblanca Julieta Griselda,
VanoyeCarlo América,
PhillipsFarfán Bryan Víctor,
CarmonaAparicio Liliana,
GómezLira Gisela
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12360
Subject(s) - synaptic vesicle , synaptotagmin 1 , kiss and run fusion , stx1a , munc 18 , neuroscience , vesicle fusion , snap25 , synaptic augmentation , neurotransmitter , synaptic fatigue , exocytosis , neurotransmission , microbiology and biotechnology , synaptic vesicle recycling , biology , chemistry , vesicle , biochemistry , inhibitory postsynaptic potential , excitatory postsynaptic potential , receptor , central nervous system , secretion , membrane
In recent years, there has been considerable interest in determining the function of synaptic vesicle protein 2A and its role as a target for antiepileptic drugs. Although it is known that synaptic vesicle protein 2A is involved in normal synaptic vesicle function, its participation in synaptic vesicle cycling and neurotransmitter release in normal and pathological conditions is unclear. However, the experimental evidence suggests that synaptic vesicle protein 2A could be a vesicular transporter, regulate synaptic exocytosis as a gel matrix, or modulate synaptotagmin‐1 activity. This review describes and discusses the participation of synaptic vesicle protein 2A in synaptic modulation in normal and pathological conditions.