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Alterations in hippocampal network oscillations and theta–gamma coupling arise before Aβ overproduction in a mouse model of A lzheimer's disease
Author(s) -
Goutagny Romain,
Gu Ning,
Cavanagh Chelsea,
Jackson Jesse,
Chabot JeanGuy,
Quirion Rémi,
Krantic Slavica,
Williams Sylvain
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12233
Subject(s) - hippocampal formation , subiculum , neuroscience , hippocampus , genetically modified mouse , coupling (piping) , psychology , transgene , alzheimer's disease , biology , disease , medicine , dentate gyrus , gene , biochemistry , mechanical engineering , engineering
Alzheimer's disease ( AD ) is an age‐related neurodegenerative disorder characterized by memory impairments. Brain oscillatory activity is critical for cognitive function and is altered in AD patients. Recent evidence suggests that accumulation of soluble amyloid‐beta ( A β) induces reorganization of hippocampal networks. However, whether fine changes in network activity might be present at very early stages, before A β overproduction, remains to be determined. We therefore assessed whether theta and gamma oscillations and their cross‐frequency coupling, which are known to be essential for normal memory function, were precociously altered in the hippocampus. Electrophysiological field potential recordings were performed using complete hippocampal preparations in vitro from young transgenic CRND 8 mice, a transgenic mouse model of AD . Our results indicate that a significant proportion of 1‐month‐old T g CRND 8 mice showed robust alterations of theta–gamma cross‐frequency coupling in the principal output region of the hippocampus, the subiculum. In addition we showed that, compared to controls, these mice expressed negligible levels of A β. Finally, these network alterations were not due to genetic factors as 15‐day‐old animals did not exhibit theta–gamma coupling alterations. Thus, initial alterations in hippocampal network activity arise before A β accumulation and may represent an early biomarker for AD .