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Cellular and molecular mechanisms controlling the migration of neocortical interneurons
Author(s) -
Marín Oscar
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12225
Subject(s) - neuroscience , glutamatergic , gabaergic , interneuron , cerebral cortex , neocortex , biology , cortex (anatomy) , glutamate receptor , inhibitory postsynaptic potential , biochemistry , receptor
The discovery, approximately 15 years ago, that cortical GABA ergic interneurons originate outside the pallium has revolutionized our understanding of the development of the cerebral cortex. It is now clear that glutamatergic pyramidal cells and GABA ergic interneurons follow largely distinct development programs, a notion that has challenged our views on how these neurons assemble to form precise neural circuits. In this review, I summarize our current knowledge of the mechanisms that control the migration of neocortical interneurons, a process that can be subdivided into three consecutive phases: migration to the cortex, intracortical dispersion, and layering.