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Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A 2A antagonism
Author(s) -
CollinsPraino Lyndsey E.,
Paul Nicholas E.,
Ledgard Felicia,
Podurgiel Samantha J.,
Kovner Rotem,
Baqi Younis,
Müller Christa E.,
Senatus Patrick B.,
Salamone John D.
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12212
Subject(s) - subthalamic nucleus , deep brain stimulation , neuroscience , psychology , dopamine , adenosine a2a receptor , antagonist , medicine , pharmacology , anesthesia , parkinson's disease , adenosine receptor , agonist , receptor , disease
Deep brain stimulation ( DBS ) of the subthalamic nucleus is increasingly being employed as a treatment for parkinsonian symptoms, including tremor. The present studies used tremulous jaw movements, a pharmacological model of tremor in rodents, to investigate the tremorolytic effects of subthalamic DBS in rats. Subthalamic DBS reduced the tremulous jaw movements induced by the dopamine D 2 family antagonist pimozide and the D 1 family antagonist ecopipam, as well as the cholinomimetics pilocarpine and galantamine. The ability of DBS to suppress tremulous jaw movements was dependent on the neuroanatomical locus being stimulated (subthalamic nucleus vs. a striatal control site), as well as the frequency and intensity of stimulation used. Importantly, administration of the adenosine A 2A receptor antagonist MSX ‐3 reduced the frequency and intensity parameters needed to attenuate tremulous jaw movements. These results have implications for the clinical use of DBS , and future studies should determine whether adenosine A 2A antagonism could be used to enhance the tremorolytic efficacy of subthalamic DBS at low frequencies and intensities in human patients.