Premium
Lateral hypothalamic involvement in feeding elicited from the ventral pallidum
Author(s) -
Stratford Thomas R.,
Wirtshafter David
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12077
Subject(s) - bicuculline , ventral pallidum , nucleus accumbens , lateral hypothalamus , basal forebrain , lesion , septal nuclei , medicine , endocrinology , forebrain , hypothalamus , antagonist , basal ganglia , basal (medicine) , neuroscience , biology , amygdala , central nervous system , receptor , pathology , globus pallidus , insulin
Intense feeding can be elicited by injections of the GABA A receptor antagonist bicuculline into the medial ventral pallidum ( VP m), a basal forebrain structure anatomically interposed between two other feeding‐related brain regions, the nucleus accumbens shell and the lateral hypothalamus ( LH ). To determine whether the VP m effects changes in feeding behavior through actions on the LH , we examined feeding following unilateral injections of bicuculline into the VP m made either ipsilateral or contralateral to a unilateral excitotoxic lesion of the LH in nondeprived rats. We found that lesions of the LH significantly attenuated feeding induced from the ipsilateral VP m, as compared to sham‐operated controls. In striking contrast, unilateral LH lesions significantly potentiated the feeding response elicited by injections of bicuculline into the contralateral VP m. The ‘ipsilateral–contralateral disruption’ design we used makes it extremely unlikely that our findings could have resulted from nonspecific effects of the lesions. These results suggest that the LH is causally involved in mediating the ingestive effects produced by activation of the VP m, and provide an important insight into the functional circuitry by which basal forebrain structures control food intake in mammals.