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Neural regulation of the time course for cocaine‐cue extinction consolidation in rats
Author(s) -
Szalay, Jonathan J.,
Jordan Chloe J.,
Kantak Kathleen M.
Publication year - 2013
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/ejn.12035
Subject(s) - anisomycin , basolateral amygdala , extinction (optical mineralogy) , psychology , neuroscience , self administration , prefrontal cortex , infralimbic cortex , amygdala , memory consolidation , addiction , hippocampus , anesthesia , medicine , chemistry , cognition , biochemistry , mineralogy , kinase
Sites within the hippocampus, amygdala and prefrontal cortex may regulate how responses maintained by cues associated with cocaine are extinguished. To test the role of various brain sites in the consolidation of cocaine‐cue extinction learning, the dorsal subiculum (d SUB ), rostral basolateral amygdala (r BLA ) and infralimbic prefrontal cortex ( IL ) were manipulated in rats. Following cocaine self‐administration training (cues present, cocaine available), responding was assessed during 1‐h extinction tests (cues present, no cocaine available). To study extinction consolidation specifically, the protein synthesis inhibitor anisomycin or vehicle was infused bilaterally into the d SUB , r BLA or IL either immediately following or 6 h after the first two of three extinction training sessions. With manipulations made immediately after extinction sessions, infusions of anisomycin into the d SUB or the r BLA deterred extinction. Rats maintained elevated levels of cocaine seeking relative to vehicle despite the absence of cocaine delivery. Manipulations of IL had no effect. Control studies showed that bilateral protein synthesis inhibition in d SUB and r BLA 6 h after the extinction sessions ended was unable to deter extinction. Rats reduced cocaine seeking in the usual manner in the absence of cocaine delivery. Collectively, these findings suggest that the d SUB and r BLA are neural substrates important for consolidation of cocaine‐cue extinction learning and have time‐dependent roles. Understanding the contribution of individual neural substrates for cocaine‐cue extinction consolidation may help guide treatment strategies aimed at enhancing cue exposure therapy in cocaine‐dependent people.