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Clinicopathological factors and tumor microenvironment markers predicting watch‐and‐wait discontinuation in 82 patients with follicular lymphoma
Author(s) -
Yuda Sayako,
Miyagi Maeshima Akiko,
Taniguchi Hirokazu,
Ito Yuta,
Hatta Shunsuke,
Suzuki Tomotaka,
Makita Shinichi,
Fukuhara Suguru,
Munakata Wataru,
Suzuki Tatsuya,
Maruyama Dai,
Izutsu Koji
Publication year - 2021
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13637
Subject(s) - discontinuation , follicular lymphoma , medicine , lymphoma , follicular phase , univariate analysis , adverse effect , international prognostic index , gastroenterology , non hodgkin's lymphoma , oncology , multivariate analysis , diffuse large b cell lymphoma
Objectives In this study, we aimed to determine the clinicopathological factors influencing the treatment‐free period in patients with follicular lymphoma (FL) using a watch‐and‐wait (WW) strategy. Methods We retrospectively assessed histopathological parameters of 82 patients with FL. Results The median time from diagnosis to WW discontinuation was 62 months (range, 3‐138), and median follow‐up was 86 months (range, 3‐183). Intermediate or high‐risk Follicular Lymphoma International Prognostic Index score ( P = .012), non‐duodenal‐type ( P = .011), higher numbers of interfollicular CD4 + ( P = .038) and intrafollicular FOXP3 + cells ( P = .024) in the tumor microenvironment, and Ki‐67 index ≥10% ( P = .031) were significant adverse factors for WW discontinuation in univariate analyses. Conclusion Patients with adverse factors for WW discontinuation should be carefully observed during follow‐up.