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Role of pre‐transplant MRD level detected by flow cytometry in recipients of allogeneic stem cell transplantation with AML
Author(s) -
Klyuchnikov Evgeny,
Christopeit Maximilian,
Badbaran Anita,
Bacher Ulrike,
FritzscheFriedland Ulrike,
Pein UteMarie,
Wolschke Christine,
Kröger Nicolaus
Publication year - 2021
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13557
Subject(s) - medicine , hazard ratio , transplantation , gastroenterology , multivariate analysis , flow cytometry , confidence interval , oncology , immunology
Objectives and Methods We analyzed the impact of pretransplant MRD level in bone marrow measured by flow cytometry using “different from normal” method on outcomes for 189 AML patients (108 males; median age, 58 (21‐80) years). All patients were subdivided into negative (n = 96), “low” (0.1%‐0.5%, n = 32), and “high” MRD (>0.5%, n = 61) groups. Results In multivariate analysis, the hazard ratios for “high” and “low” MRD levels related to MRD negativity were 7.9 (95% CI 3.5‐18.1, P < .001) and 5.4 (95% CI 2.1‐14, P = .0058) for relapse; 2.3 (95% CI 1.3‐4.1, P = .006) and 1.6 (95% CI 0.82‐3.3, P = .16) for OS; and 2.8 (95% CI 1.7‐4.7, P < .001) and 2.2 (95% CI 1.1‐4.2, P = .02) for LFS, respectively. We found no significant impact of “low” MRD level on relapses (0.68, 95% CI 0.33‐1.4, P = .30), OS (0.72, 95% CI: 0.36‐1.5, P = .36) and LFS (0.79, 95% CI: 0.42‐1.5, P = .46) related to “high” MRD group. Conclusions Presence of detectable MRD was indicative for a high relapse risk, low LFS and OS. “Low” MRD level showed no significant impact on relapse, LFS and OS related to “high” MRD group.