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Current understanding and future implications of sepsis‐induced thrombocytopenia
Author(s) -
Ghimire Subash,
Ravi Swapna,
Budhathoki Rasmita,
Arjyal Lubina,
Hamal Savyata,
Bista Amir,
Khadka Sushmita,
Uprety Dipesh
Publication year - 2021
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13549
Subject(s) - sepsis , medicine , intensive care medicine , resuscitation , modalities , immunology , emergency medicine , social science , sociology
Abstract Sepsis is a global health burden that needs intensive medical care. Thrombocytopenia in sepsis is well known to increase morbidity as well as mortality. Several studies have been performed both in animal models and in humans to understand the mechanism by which sepsis causes thrombocytopenia. Recent studies have shown that inhibiting thrombocytopenia improves outcomes in sepsis patients. Understanding these mechanisms to identify targets in use of newer treatment modalities besides using resuscitation measures, antibiotics and removal of thrombocytopenia inducing agent could potentially help us improve outcomes in sepsis.