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Monocenter study on epidemiology, outcomes, and risk factors of infections in recipients of 166 allogeneic stem cell transplantations during 1 year
Author(s) -
Samek Markus,
Iversen Katharina,
Belmar Campos Cristina,
Berneking Laura,
Langebrake Claudia,
Wolschke Christine,
Ayuk Francis,
Kröger Nicolaus,
Christopeit Maximilian
Publication year - 2020
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13416
Subject(s) - medicine , leukopenia , neutropenia , cumulative incidence , epidemiology , incidence (geometry) , sepsis , hematopoietic stem cell transplantation , transplantation , risk factor , septic shock , pediatrics , surgery , chemotherapy , optics , physics
Objectives During allogeneic hematopoietic stem cell transplantation (allo‐SCT), infections significantly contribute to morbidity and mortality. A monocentric prospective analysis was performed to assess epidemiology, risk factors, and outcomes of infections during the peri‐transplant period. Methods Data were recorded prospectively using a predefined questionnaire. Results In 2015, 163 consecutive patients, 37.4% female, median age 59 (range 18‐79) years received 166 allo‐SCT. Median duration of leukopenia <10 9 /L was 14.5 days (range 4‐43 days). Fever of unknown origin (FUO) occurred in 118/166 patients (71.1%). Severe sepsis developed in 95, and septic shock developed in 26 patients. Intensive diagnostic workup helped to identify causative microorganisms only in a small number of infectious courses. All but 13 patients needed antibiotic therapy, each according to the standard operating procedures of the department. Cumulative incidence of death by infection after 1 year was 16.6% (95% CI: 11.3‐22.7). The only risk factor for FUO in neutropenia was duration of neutropenia