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Validity of plasma collection cards for ferritin assessment—A proof‐of‐concept study
Author(s) -
Koehler Karsten,
MarksNelson Eileen,
Braga Camila P.,
Beckford Safiya,
Adamec Jiri
Publication year - 2020
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13397
Subject(s) - concordance , ferritin , hematocrit , hemoglobin , medicine , venous blood , concordance correlation coefficient , blood collection , surgery , emergency medicine , statistics , mathematics
Objectives Iron depletion is common around the world and among certain risk groups in developed countries. The overall purpose was to test the suitability of a novel plasma collection card for minimally invasive iron status assessment. Methods Twenty participants (10 f/10 m) participated in this cross‐sectional study. Ferritin and hemoglobin were measured from blood collected from a forearm vein, serving as reference method. Blood was also collected from the fingertip using the Noviplex TM Plasma Prep Card as well as capillary collection tubes. Results There was substantial concordance between ferritin measured from samples collected via Noviplex TM and venous ferritin (concordance correlation coefficient (CCC) = 0.96) with a mean bias of −0.8 ng/mL. Storing Noviplex TM cards at room temperature for 2 weeks resulted in slightly lower but good concordance when compared to venous ferritin (CCC = 0.95). Capillary hemoglobin (CCC = 0.42) and hematocrit (CCC = 0.25) were in poor agreement with venous data. Conclusions Noviplex TM cards offer a suitable alternative for a minimally invasive ferritin screening in the field when compared to capillary collection tubes. Despite overall substantial concordance with the reference method, findings indicative of iron status abnormalities should be confirmed in venous samples.