All‐ trans  retinoic acid (ATRA)‐induced  TFEB  expression is required for myeloid differentiation in acute promyelocytic leukemia (APL) | Zendy

Orfali Nina | Zendy; O'Donovan Tracey R. | Zendy; Cahill Mary R. | Zendy; Benjamin Dalyia | Zendy; Nanus David M. | Zendy; McKenna Sharon L. | Zendy; Gudas Lorraine J. | Zendy; Mongan Nigel P. | Zendy

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All‐ trans retinoic acid (ATRA)‐induced TFEB expression is required for myeloid differentiation in acute promyelocytic leukemia (APL)

Author(s) -

Orfali Nina,

O'Donovan Tracey R.,

Cahill Mary R.,

Benjamin Dalyia,

Nanus David M.,

McKenna Sharon L.,

Gudas Lorraine J.,

Mongan Nigel P.

Publication year - 2020

Publication title -

european journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0902-4441

DOI - 10.1111/ejh.13367

Subject(s) - tfeb , autophagy , acute promyelocytic leukemia , myeloid leukemia , microbiology and biotechnology , retinoid , biology , cancer research , retinoic acid , transcription factor , myeloid , cellular differentiation , cell culture , biochemistry , apoptosis , genetics , gene

In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by an abnormal PML-RARα fusion oncoprotein, leading to a block in cell differentiation. Therapeutic concentrations of all-trans-retinoic acid (ATRA) can restore retinoid-induced transcription and promote degradation of the PML-RARα protein. Autophagy is a catabolic pathway that utilizes lysosomal machinery to degrade intracellular material and facilitate cellular re-modeling. Recent studies have identified autophagy as an integral component of ATRA-induced myeloid differentiation.

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