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A very potent factor V inhibitor interferes with the levels of all coagulation factors and causes a fatal hemorrhagic syndrome
Author(s) -
Hoffmann Claire,
Amiral Jean,
Rezig Schéhérazade,
Kerspern Hélène,
Jantzem Hélène,
Robin Sara,
Collins Adam,
Mornet Clelia,
Mingant Fanny,
Pan Petesch Brigitte,
Ianotto JeanChristophe,
Lippert Eric,
Galinat Hubert
Publication year - 2019
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13249
Subject(s) - coagulation , fibrinogen , tissue factor pathway inhibitor , medicine , coagulation disorder , pharmacology , gastroenterology , immunology , tissue factor
We report a very high factor V inhibitor affecting the measurement of all coagulation factors besides fibrinogen, all these factors being dramatically decreased. This inhibitor could be linked to antibiotic use. The patient died of massive hemorrhage before a plasma exchange could be initiated.