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Impact of ruxolitinib pretreatment on outcomes after allogeneic stem cell transplantation in patients with myelofibrosis
Author(s) -
Shahnaz Syed Abd Kadir Sharifah,
Christopeit Maximilian,
Wulf Gerald,
Wagner Eva,
Bornhauser Martin,
Schroeder Thomas,
Crysandt Martina,
Mayer Karin,
Jonas Julia,
Stelljes Matthias,
Badbaran Anita,
Ayuketang Ayuk Francis,
Triviai Ioanna,
Wolf Dominik,
Wolschke Christine,
Kröger Nicolaus
Publication year - 2018
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13099
Subject(s) - ruxolitinib , myelofibrosis , medicine , transplantation , stem cell , oncology , biology , bone marrow , genetics
Abstract Introduction Ruxolitinib is the first approved drug for treatment of myelofibrosis, but its impact of outcome after allogeneic stem cell transplantation ( ASCT ) is unknown. Patients and methods We reported on 159 myelofibrosis patients (pts) with a median age of 59 years ( r : 28‐74) who received reduced intensity ASCT between 2000 and 2015 in eight German centers from related (n = 23), matched (n = 86) or mismatched (n = 50) unrelated donors. Forty‐six (29%) patients received ruxolitinib at any time point prior to ASCT . The median daily dose of ruxolitinib was 30 mg (range 10‐40 mg) and the median duration of treatment was 4.9 months (range 0.4‐39.1 months). Results Primary graft failure was seen in 2 pts (4%) in the ruxolitinib and 3 (2%) in the non‐ruxolitinib group. Engraftment and incidence of acute GVHD grade II to IV and III / IV did not differ between groups (37% vs 39% and 19% vs 28%, respectively), nor did the non‐relapse mortality at 2 years (23% vs 23%). A trend for lower risk of relapse was seen in the ruxolitinib group (9% vs 17%, P = .2), resulting in a similar 2 year DFS and OS (68% vs 60% and 73% vs 70%, respectively). No difference in any outcome variable could be seen between ruxolitinib responders and those who failed or lost response to ruxolitinib. Conclusions These results suggest that ruxolitinib pretreatment in myelofibrosis patient does not negatively influence outcome after allogeneic stem cell transplantation.