Premium
Efficacy and safety of rivaroxaban compared to enoxaparin in treatment of cancer‐associated venous thromboembolism
Author(s) -
Simmons Benjamin,
Wysokinski Waldemar,
Saadiq Rayya A.,
BottKitslaar Dalene,
Henkin Stanislav,
Casanegra Ana,
Lenz Charles,
Daniels Paul,
Bjarnason Haraldur,
Vargas Emily,
Hodge David,
Holton Sara J.,
Cerhan James R.,
Loprinzi Charles,
McBane Robert
Publication year - 2018
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13074
Subject(s) - rivaroxaban , medicine , low molecular weight heparin , cancer , incidence (geometry) , surgery , pulmonary embolism , guideline , heparin , warfarin , atrial fibrillation , physics , pathology , optics
Background Low molecular weight heparin ( LMWH ) is the guideline‐endorsed treatment for cancer‐associated venous thromboembolism ( cVTE ). Study objectives were to compare the efficacy and safety of rivaroxaban and enoxaparin in cVTE . Methods Using a cohort study design, consecutive patients with cVTE (3/1/2013‐7/31/2016), enrolled in the Mayo Thrombophilia Clinic Direct Oral Anticoagulants Registry, were compared to contemporary cancer patients receiving enoxaparin. The cumulative incidence of venous thromboembolism ( VTE ) recurrence, major and clinically relevant non‐major bleeding, and survival were assessed at 3 and 12 months. Results Ninety‐eight patients received rivaroxaban (51% female, mean age 63 ± 12 years) and 168 enoxaparin (34.5% female, mean age 62 ± 15 years). The most common cancers included gastrointestinal/pancreatic, genitourinary and hematologic cancers. More than half of patients had pulmonary emboli at presentation. More than half had metastases, and two‐thirds were receiving chemotherapy. At 3 months, there were no differences in VTE recurrence (rivaroxaban 1.0% vs enoxaparin 4.2%; P = .15), major bleeding (rivaroxaban 5.1% vs enoxaparin 3.6%; P = .55), or all‐cause mortality (rivaroxaban 4.1% vs enoxaparin 8.9%; P = .14). At 12 months, these outcomes did not differ by treatment strategy. Conclusion The results of this “real‐world” experience with cVTE suggest that rivaroxaban may offer a safe and effective alternative to LMWH .