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Associations between fatigue, physical activity, and QoL in patients with myeloproliferative neoplasms
Author(s) -
Tolstrup Larsen Rasmus,
Tang Lars H.,
Brochmann Nana,
Meulengracht Flachs Esben,
Illemann Christensen Anne,
Hasselbalch Hans C.,
Zwisler AnnDorthe
Publication year - 2018
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13048
Subject(s) - medicine , quality of life (healthcare) , physical activity , myeloproliferative neoplasm , intervention (counseling) , physical therapy , chronic fatigue , chronic fatigue syndrome , myelofibrosis , psychiatry , bone marrow , nursing
Background Patients with Philadelphia chromosome‐negative Myeloproliferative Neoplasms ( MPN s) report fatigue as the most common symptom and contributing significantly to reduction in their quality of life (QoL). Targeted non‐pharmacological intervention to increase levels of physical activity is suggested as a fatigue‐reducing and QoL‐enhancing intervention in MPN patients. The interrelationship between physical activity, fatigue, and QoL has, to our knowledge, never been reported. Methods We analyzed data from 1807 MPN patients. The primary analysis included a multiple regression model allowing fatigue to mediate the relationship between physical activity and QoL. Results We herein report the first and the largest study of patients with MPN s, in whom we have investigated the interrelationship between fatigue, physical activity, and QoL. Sedentary patients were more likely to report fatigue compared to highly active patients. There was a negative association between fatigue and QoL, and there was a positive association between physical activity and QoL. There was no interaction between fatigue and physical activity in the association with QoL. Conclusion We found positive associations between level of physical activity and QoL, independently of fatigue being present. More research is needed before physical activity can be introduced as a targeted intervention to reduce fatigue and increase QoL in the management of patients.