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Assessments of pain, functional impairment, anxiety, and depression in US adults with hemophilia across patient‐reported outcome instruments in the Pain, Functional Impairment, and Quality of Life (P‐FiQ) study
Author(s) -
Buckner Tyler W.,
Batt Katharine,
Quon Doris,
Witkop Michelle,
Recht Michael,
Kessler Craig,
Baumann Kimberly,
Hernandez Grace,
Wang Michael,
Cooper David L.,
Kempton Christine L.
Publication year - 2018
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.13027
Subject(s) - quality of life (healthcare) , anxiety , medicine , depression (economics) , functional impairment , physical therapy , visual analogue scale , activities of daily living , affect (linguistics) , disease , psychiatry , psychology , nursing , communication , economics , macroeconomics
Pain, functional impairment, anxiety, and depression associated with joint disease may affect health‐related quality of life (HRQoL) in people with hemophilia. Objective To report detailed patient‐reported outcomes (PRO) assessments related to HRQoL in participants in the Pain, Functional Impairment, and Quality of Life (P‐FiQ) study. Methods Pain and HRQoL were assessed via PRO instruments in US adult males with hemophilia A or B and a history of joint pain or bleeding. PRO instruments included EQ‐5D‐5L with visual analog scale, Brief Pain Inventory v2 Short Form, SF‐36v2, and Hemophilia Activities List. Instrument domain and item responses were described. Results Responses were collected from 381 adult males with a median age of 34 years. Pain was observed across instruments and affected daily activities and quality of life. Respondents reported functional impairment that limited the kind of work and activities they participated in, with activities involving the lower extremities being most affected. A high prevalence of mental health disorders was identified across instruments. Conclusions Pain and HRQoL were evaluated using multiple PRO instruments, which vary in timescales of assessment and levels of detail. More consistent clinical assessments and patient dialog regarding pain and aspects of HRQoL may help drive improved outcomes.