Premium
Waldenström′s macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection
Author(s) -
Growková Kateřina,
Kryukova Elena,
Kufová Zuzana,
Filipová Jana,
Ševčíková Tereza,
Říhová Lucie,
Kaščák Michal,
Kryukov Fedor,
Hájek Roman
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12959
Subject(s) - clone (java method) , waldenstrom macroglobulinemia , somatic hypermutation , immunophenotyping , monoclonal , biology , somatic evolution in cancer , macroglobulinemia , population , immunology , plasma cell , b cell , cancer research , monoclonal antibody , antigen , genetics , medicine , cancer , lymphoma , antibody , gene , environmental health , multiple myeloma
Waldenström′s macroglobulinemia ( WM ) is a complex disease characterized by apparent morphological heterogeneity within the malignant clonal cells representing a continuum of small lymphocytes, plasmacytoid lymphocytes, and plasma cells. At the molecular level, the neoplastic B cell–derived clone has undergone somatic hypermutation, but not isotype switching, and retains the capability of plasmacytic differentiation. Although by classical definition, WM is formed by monoclonal expansion, long‐lived clonal B lymphocytes are of heterogeneous origin. Even more, according to current opinion, plasma cells also conform certain population with pathogenic and clinical significance. In this article, we review the recent advances in the WM clonal architecture, briefly describe B‐cell development during which the molecular changes lead to the malignant transformation and mainly focus on differences between two principal B‐lineage clones, including analysis of their genome and transcriptome profiles, as well as immunophenotype features. We assume that the correct identification of a number of specific immunophenotypic molecular and expression alterations leading to proper aberrant clone detection can help to guide patient monitoring throughout treatment and successfully implement therapy strategies directed against both B‐ and plasma cell tumor WM clones.