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The prognostic value of a trend in modified SOFA score for patients with hematological malignancies in the intensive care unit
Author(s) -
Demandt Astrid M.P.,
Geerse Daniël A.,
Janssen Bram J.P.,
Winkens Bjorn,
Schouten Harry C.,
Mook Walther N.K.A.
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12919
Subject(s) - sofa score , medicine , intensive care unit , odds ratio , retrospective cohort study , cohort , mortality rate
Background Patients with hematological malignancies admitted to an intensive care unit ( ICU ) have a poor prognosis. The Sequential Organ Failure Assessment ( SOFA ) score is used to monitor patients on the ICU . Little is known about the value of this score in hematology patients. Therefore, the prognostic value of the SOFA score and a modified hematological SOFA score ( SOFA hem) was studied. Methods Patients with hematological malignancies admitted to the ICU between 1999 and 2009 were analyzed in a retrospective cohort study. The SOFA hem score was defined as the original SOFA score omitting the coagulation and neurological parameters. Results In 149 admissions, ICU mortality was 52%. Mortality was significantly associated with higher SOFA and SOFA hem scores on admission, and trend in SOFA hem scores. An unchanged and increased SOFA hem score compared to decreasing SOFA hem scores was associated with a higher mortality rate (53% resp 67% resp 25%). Conclusions Trends in SOFA or SOFA hem score are both suitable as prognostic parameter. The trend in SOFA hem score seems to be independently related to mortality in hematological patients admitted to the ICU , and because of the higher odds ratios and lower P ‐values compared to the SOFA score, it is probably stronger related to mortality than the classical score, but its prognostic value should be tested in a larger cohort.