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ABCG2 and CD200 define patients at high risk of relapse in ELN favorable subgroup of AML
Author(s) -
Tiribelli Mario,
Geromin Antonella,
Cavallin Margherita,
Di Giusto Sara,
Simeone Erica,
Fanin Renato,
Damiani Daniela
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12915
Subject(s) - medicine , myeloid leukemia , relative risk , leukemia , gastroenterology , oncology , confidence interval
Objective Overexpression of ABCG 2 and CD 200 has been independently associated with poor outcome in acute myeloid leukemia ( AML ). However, no data are available on the role of these two factors in patients with core‐binding factor ( CBF )‐positive or FLT 3‐negative/ NPM 1‐mutated cytogenetically normal ( CN ) AML . Methods We analyzed 65 adult AML patients with CBF + (n=16) or FLT 3−/ NPM 1+ CN (n=49), evaluating clinical and biological factors associated with complete remission attainment, leukemia‐free survival ( LFS ) and overall survival ( OS ). Results ABCG 2 was expressed in 36 (55%) cases, and CD 200 was positive in 33 (51%) cases, six at high levels. Both ABCG 2 and CD 200 positivity have a negative impact on relapse risk: 3‐year LFS was 51% vs 82% in ABCG 2+ cases ( RR 3.3), 49% vs 82% in CD 200+ patients ( RR =4.4), and 25% in CD 200− high cases ( RR =17.1). ABCG 2 and CD 200 affected also OS with 3‐year OS of 39% in ABCG 2+ (compared to 71% in ABCG 2−; RR =2.6) and CD 200+ (compared to 68% in CD 200−; RR =2.5) patients. Conclusions Our data confirm a negative impact of ABCG 2 and CD 200 overexpression also in AML patients considered at favorable risk according to ELN cytogenetic/molecular classification.