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Potential roles of microRNAs and their target genes in human multiple myeloma
Author(s) -
Yang Yong,
Lin Jisheng,
Ma Zhao,
Li Jinjun,
Li Dong,
Wang Bingqiang,
Fei Qi
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12901
Subject(s) - microrna , rna , gene , messenger rna , gene expression , biology , pathogenesis , disease , context (archaeology) , non coding rna , multiple myeloma , cancer research , bioinformatics , genetics , medicine , immunology , pathology , paleontology
Objectives The etiology of multiple myeloma ( MM ) is unknown and it remains incurable. We sought to elucidate the mechanisms underlying mi RNA s involvement in MM pathogenesis. Methods Public mRNA and mi RNA expression datasets for MM were collected from the Gene Expression Omnibus database. By integrated bioinformatics analysis, the expression signatures were identified and the mi RNA ‐ mRNA interaction network was constructed. The potential functions of target genes were then explored by functional enrichment analysis. Results Totally, 839 differentially expressed mRNA s and six differentially expressed mi RNA s were identified. The context of mi RNA s‐mediated genes regulatory network consisted of 288 possible mi RNA ‐ mRNA target pairs. The hub mi RNA was hsa‐miR‐92a, which can serve as the indicator for MM disease status. Another mi RNA , hsa‐miR‐148a, could be useful for prognosis of MM . Functional annotation revealed that the mi RNA targets may play important roles in viral infection and proteasome. Moreover, mi RNA targets may be involved in renal cell carcinoma and other nervous system disease such as Huntington's disease, Alzheimer's disease and Parkinson's disease, which may be subsequent complications of MM. Conclusions Infections could be a leading cause for the morbidity of MM patients. The crucial protein degradation machinery may be essential in the pathogenesis of MM .