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Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with 5‐azacitidine
Author(s) -
Radsak Markus,
Platzbecker Uwe,
Schmidt Cornelia S.,
Hofmann WolfKarsten,
Nolte Florian
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12883
Subject(s) - myelodysplastic syndromes , azacitidine , medicine , peripheral blood , intensive care medicine , immunology , bone marrow , biology , biochemistry , gene expression , dna methylation , gene
Abstract Myelodysplastic Syndromes are oligo‐clonal stem cell disorders that are associated with cytopenias in the peripheral blood. Major causes for morbidity and mortality in myelodysplastic syndromes ( MDS ) patients are infections mostly due to bacteria or fungi. Beside leucopenia per se in affected patients, function of white blood cells particularly that of neutrophils seems to be impaired. Here we summarize the available data on infections in MDS patients in general and particularly those treated with 5‐azacitidine.