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Comparison of clinicopathological characteristics between T‐cell prolymphocytic leukemia and peripheral T‐cell lymphoma, not otherwise specified
Author(s) -
Kawamoto Keisuke,
Miyoshi Hiroaki,
Yanagida Eriko,
Yoshida Noriaki,
Kiyasu Junichi,
Kozai Yasuji,
Morikita Tatsuma,
Kato Takeharu,
Suzushima Hitoshi,
Tamura Shinobu,
Muta Tsuyoshi,
Kato Koji,
Eto Tetsuya,
Seki Ritsuko,
Nagafuji Koji,
Sone Hirohito,
Takizawa Jun,
Seto Masao,
Ohshima Koichi
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12856
Subject(s) - prolymphocytic leukemia , medicine , peripheral t cell lymphoma , not otherwise specified , lymphoma , gastroenterology , leukemia , pathology , t cell lymphoma , t cell , immunology , chronic lymphocytic leukemia , immune system
Objectives T‐cell prolymphocytic leukemia (T‐ PLL ) is a very rare, aggressive T‐cell neoplasm. Peripheral T‐cell lymphoma, not otherwise specified ( PTCL ‐ NOS ) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T‐ PLL and PTCL ‐ NOS . Methods We analyzed 15 T‐ PLL and 91 PTCL ‐ NOS patients and also compared clinical features between T‐ PLL and PTCL ‐ NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared. Results T‐PLL cells were smaller in size than those of PTCL ‐ NOS with leukemic presentation ( P =.0068); moreover, PTCL ‐ NOS cells with leukemic presentation were smaller than those of PTCL ‐ NOS without leukemic presentation ( P =.0017). Immunophenotypic patterns in T‐ PLL and PTCL ‐ NOS were similar. Five‐year overall survival rates of T‐ PLL and all PTCL ‐ NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T‐ PLL and PTCL ‐ NOS with leukemic presentation had essentially equivalent characteristics. Conclusion T‐PLL and PTCL ‐ NOS may share common biological and clinical characteristics in Japanese patients.