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Are myelodysplastic syndromes underdiagnosed in Poland? A report by the Polish Adult Leukaemia Group
Author(s) -
DrozdSokołowska Joanna E.,
Mądry Krzysztof,
WaszczukGajda Anna,
Żółtak Tomasz,
Sikorska Anna,
Mital Andrzej,
Wajs Jarosław,
Semeńczuk Grażyna,
SzmigielskaKapłon Anna,
Szczepańska Magdalena,
Wasilewska Ewa,
Szwedyk Paweł,
Hołojda Jadwiga,
Wątek Marzena,
StellaHołowiecka Beata,
SorokaWojtaszko Maria,
Homenda Wojciech,
Polak Mirosław,
GuzickaKazimierska Renata,
Porowska Agnieszka,
WiktorJędrzejczak Wiesław,
DwilewiczTrojaczek Jadwiga
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12814
Subject(s) - medicine , myelodysplastic syndromes , epidemiology , incidence (geometry) , myeloid leukaemia , cytopenia , pediatrics , dysplasia , bone marrow , physics , optics
Objectives The epidemiology of myelodysplastic syndromes ( MDS ) differs among countries. Here, we present the first epidemiological indices determined for Poland. Methods Twenty‐one haematological centres participated in the study. Patients diagnosed with MDS and acute myeloid leukaemia ( AML ) with 20–29% blasts were enrolled. Data collection was conducted for strictly predefined period. Results The overall crude incidence rate for all MDS subtypes was 1.95 (95% CI , 1.81–2.09) per 100 000 person‐years: 2.46 (95% CI , 2.24–2.69) for males and 1.47 (95% CI , 1.31–1.65) for females; after excluding AML cases, the indices were as follows: 2.35 (95% CI , 2.08–2.66) for males and 1.27 (95% CI , 1.08–1.5) for females. Prevalence rate was 6.2 per 100 000 persons (95% CI , 5.96–6.45), that is 6.86 (95% CI , 6.49–7.24) for males and 5.58 (95% CI , 5.26–5.92) for females. Both incidence and prevalence increased with increasing age. The most frequently diagnosed MDS subtype was refractory cytopenia with multilineage dysplasia ( RCMD ), responsible for 30.3% of all newly diagnosed MDS s. Conclusions RCMD is the most frequent MDS subtype in Poland. Incidence and prevalence indices are lower than those reported for other populations, which probably results from inadequate diagnosis of potential cases of this disease.