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Hyperdiploidy as a rare event that accompanies poor prognosis markers in CLL
Author(s) -
GonzálezGascón y Marín Isabel,
Martín Ana África,
HernándezSanchez María,
Robledo Cristina,
Hermosín María Lourdes,
Heras Natalia,
Lacalle Laura,
Galende Josefina,
Arriba Felipe,
RodríguezVicente Ana Eugenia,
Hernández JoséÁngel,
HernándezRivas Jesús María
Publication year - 2017
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12812
Subject(s) - medicine , oncology , fish <actinopterygii> , trisomy , biology , genetics , fishery
The presence of chromosomal gains other than trisomy 12 in chronic lymphocytic leukaemia ( CLL ) is unusual. However, some patients may show gains on several chromosomes simultaneously suggesting a hyperdiploid karyotype. Objective The objective of this study was to analyse by FISH the frequency and prognostic impact of hyperdiploidy in CLL . Method A review of 1359 consecutive cases diagnosed with CLL referred for FISH analysis to a unique institution was carried out. Hyperdiploidy was considered when a gain of at least three of the five FISH probes used was observed. Results Seven cases (0.51%) with hyperdiploidy were found, confirming that it is a rare event in this disease. Although most patients presented with early Binet stages at diagnosis, six of seven (86%) shortly progressed. The median of time to the first therapy ( TTFT ) and overall survival ( OS ) for the patients with hyperdiploidy were short (1.4 months and 20 months, respectively). Moreover, comparing them with a control group of patients (non‐hyperdiploid) with completed follow‐up data, TTFT and OS of the patients with hyperdiploidy were significantly shorter than the control group. Conclusion The presence of hyperdiploidy is uncommon and probably associated with poor prognostic markers in CLL .