Premium
Genomewide profiling of copy‐number alteration in monoclonal gammopathy of undetermined significance
Author(s) -
Mikulasova Aneta,
Smetana Jan,
Wayhelova Marketa,
Janyskova Helena,
Sandecka Viera,
Kufova Zuzana,
Almasi Martina,
Jarkovsky Jiri,
Gregora Evzen,
Kessler Petr,
Wrobel Marek,
Walker Brian A.,
Wardell Christopher P.,
Morgan Gareth J.,
Hajek Roman,
Kuglik Petr
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12774
Subject(s) - monoclonal gammopathy of undetermined significance , multiple myeloma , pathology , monoclonal , gastroenterology , medicine , biology , immunology , monoclonal antibody , antibody
Monoclonal gammopathy of undetermined significance ( MGUS ) is a benign condition with an approximate 1% annual risk of symptomatic plasma cell disorder development, mostly to multiple myeloma ( MM ). We performed genomewide screening of copy‐number alterations ( CNA s) in 90 MGUS and 33 MM patients using high‐density DNA microarrays. We identified CNA s in a smaller proportion of MGUS (65.6%) than in MM (100.0%, P = 1.31 × 10 −5 ) and showed median number of CNA s is lower in MGUS (3, range 0–22) than in MM (13, range 4–38, P = 1.82 × 10 −10 ). In the MGUS cohort, the most frequent losses were located at 1p (5.6%), 6q (6.7%), 13q (30.0%), 14q (14.4%), 16q (8.9%), 21q (5.6%), and gains at 1q (23.3%), 2p (6.7%), 6p (13.3%), and Xq (7.8%). Hyperdiploidy was detected in 38.9% of MGUS cases, and the most frequent whole chromosome gains were 3 (25.6%), 5 (23.3%), 9 (37.8%), 15 (23.3%), and 19 (32.2%). We also identified CNA s such as 1p, 6q, 8p, 12p, 13q, 16q losses, 1q gain and hypodiploidy, which are potentially associated with an adverse prognosis in MGUS . In summary, we showed that MGUS is similar to MM in that it is a genetically heterogeneous disorder, but overall cytogenetic instability is lower than in MM , which confirms that genetic abnormalities play important role in monoclonal gammopathies.