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Ultrasound‐guided core needle biopsies for workup of lymphadenopathy and lymphoma
Author(s) -
Groneck Laura,
Quaas Alexander,
Hallek Michael,
Zander Thomas,
Weihrauch Martin R.
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12742
Subject(s) - medicine , lymphoma , biopsy , radiology , medical diagnosis , lymph node , lymph node biopsy , sampling (signal processing) , ultrasound , carcinoma , complication , surgery , pathology , filter (signal processing) , computer science , computer vision
Background For the histopathological diagnosis of lymphoma, lymph node excision biopsies are regarded as standard of care. In contrast, for the diagnosis of carcinoma and deep‐seated tumors, core needle biopsies ( CNB s) are accepted as a sufficient sampling method. We evaluated a diagnostic algorithm for peripheral lymphadenopathy starting with ultrasound‐guided CNB followed by excisional biopsy in ambiguous cases. Methods We performed ultrasound‐guided CNB of peripheral lymph nodes and subcutaneous tumors in patients with lymphadenopathy in routine care and analyzed its accuracy, complication rate, and the impact of needle sizes on results. Results From 138 patients, 132 samples were technically adequate. In 121 patients, CNB provided a clinically actionable diagnosis (76 lymphoma, 30 carcinoma, 15 non‐malignant diagnoses). A total of 54 patients had a secondary biopsy. Inconclusive diagnoses were rare with two false‐positive and two false‐negative non‐Hodgkin's lymphoma, and higher for Hodgkin's lymphoma with five false‐negative cases. The rate of complications was low. Needle size did not significantly influence results. Conclusion Ultrasound‐guided CNBs are a safe, quick, and valid tool for the workup of lymphadenopathy. Yet, a benign diagnosis from CNB must be completed by a secondary biopsy if clinical presentation suggests malignant disease.