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Chronic myeloid leukemia in the Netherlands: a population‐based study on incidence, treatment, and survival in 3585 patients from 1989 to 2012
Author(s) -
Thielen Noortje,
Visser Otto,
Ossenkoppele Gert,
Janssen Jeroen
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12695
Subject(s) - medicine , incidence (geometry) , relative survival , cancer registry , population , myeloid leukemia , demography , cancer , pediatrics , environmental health , physics , sociology , optics
Abstract Objective To assess the impact and results of treatment of CML in the general population, we conducted a population‐based, nationwide study on 3585 CML patients diagnosed between 1989 and 2012 in the Netherlands. Methods Patient demographics were obtained from the Netherlands Cancer Registry. Information on age, gender, year of diagnosis, first treatment, and date of death were recorded. Overall survival ( OS ) was adjusted for death rates in the normal population. Results Incidence in males decreased slightly from 1.2 per 100.000 person years ( PY ) in 1989–2000 to 0.9 in 2001–2012. For females, incidence remained stable with 0.7 per 100.000 PY in both periods. Incidence was age dependent and highest in males in the last decades of life. Treatment before 2000 mainly consisted of chemotherapy, while after 2007 TKI use was 88%. Five‐year relative survival was only 36% before the introduction of TKI s but significantly increased to 79% after the introduction of TKI . Conclusions This study gives insight into CML incidence, treatment, and survival in routine care in the Netherlands. Although OS improved since the introduction of TKI s, there is still room for further improvement.