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Cytogenetics in multiple myeloma patients progressing into extramedullary disease
Author(s) -
Besse Lenka,
Sedlarikova Lenka,
Greslikova Henrieta,
Kupska Renata,
Almasi Martina,
Penka Miroslav,
Jelinek Tomas,
Pour Ludek,
Adam Zdenek,
Kuglik Petr,
Krejci Marta,
Hajek Roman,
Sevcikova Sabina
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12688
Subject(s) - multiple myeloma , fluorescence in situ hybridization , bone marrow , pathology , medicine , cytogenetics , biology , chromosome , genetics , gene
Background Extramedullary disease in multiple myeloma patients is an uncommon event occurring either at the time of diagnosis, or during disease progression/relapse. This manifestation is frequently associated with poor outcome and resistance to treatment. We evaluated chromosomal alterations of plasma cells of multiple myeloma patients with extramedullary relapse, either in the bone marrow (BM) or at extramedullary sites, and in previous BM collection by interphase fluorescence in situ hybridization. Material and methods Thirty‐one patients [25 BM plasma cells (BMPCs), 18 extramedullary tumor plasma cells], of which 12 had paired samples of BM and extramedullary plasma cells and 14 had previous collection of BM, were investigated for the presence of chromosomal aberrations (CHAs): del(17)(p13), del(13)(q14), 14q32 disruption, t(4;14)(p16;q32), t(14;16)(q32;q23), gain(1)(q21), and hyperdiploidy status. Results Overall, in unrelated samples, t(4;14) was more prevalent in extramedullary plasma cells, and hyperdiploidy was more frequent in BMPCs. In paired samples, there was a higher frequency of del(13)(q14) and 14q32 disruption in BMPCs. Frequency of all studied CHAs was higher in BMPCs of extramedullary patients than in their previous sample collection. Conclusion These data show that plasma cells harbor more aberrations during their transformation into extramedullary form.