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High incidence of engraftment syndrome after haploidentical allogeneic stem cell transplantation
Author(s) -
Chen Yao,
Xu LanPing,
Liu KaiYan,
Chen Huan,
Chen YuHong,
Zhang XiaoHui,
Wang Yu,
Wang FengRong,
Han Wei,
Wang JingZhi,
Yan ChenHua,
Zhang YuanYuan,
Sun YuQian,
Huang XiaoJun
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12629
Subject(s) - medicine , incidence (geometry) , rash , transplantation , gastroenterology , diarrhea , hematopoietic stem cell transplantation , surgery , physics , optics
We determined the incidence, clinical manifestations, and outcomes of engraftment syndrome ( ES ) in haploidentical stem cell transplantation ( SCT ) recipients. We compared the incidence of ES between the patient group that received haploidentical SCT ( n = 516) and the patient group that received HLA ‐identical sibling SCT ( n = 393). The transplantations were performed in the Peking University People's Hospital in the period between October 2001 and October 2012. The ES incidence data were collected retrospectively. Patients that presented non‐infectious fever or skin rash within the 24‐h window before or after the beginning of neutrophil recovery were diagnosed with ES in accordance with the Maiolino criteria. ES incidence in haploidentical SCT recipients (21.9%) was significantly higher than that in HLA ‐identical sibling SCT recipients (2.0%; P < 0.001). Major symptoms included fever (119/121, 98.3%), skin rash (98/121, 81.0%), and diarrhea (51/121, 42.1%), with the median time of +10 d (range: 6–20 d). The median C‐reactive protein level of the ES group (99.0 mg/L; n = 13) was significantly higher than that of the non‐ ES group (13.9 mg/L; n = 38; P < 0.001). Similarly, the results showed that the median C3 plasma concentration of the ES group (1.30 g/L) was higher than that of the non‐ ES group (1.16 g/L, P = 0.003). ES was not associated with non‐relapse mortality or overall survival. High incidence of ES was observed in haploidentical SCT recipients; however, ES did not predict poor clinical outcomes.