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A multicentre observational study for early diagnosis of Gaucher disease in patients with Splenomegaly and/or Thrombocytopenia
Author(s) -
Motta Irene,
Filocamo Mirella,
Poggiali Erika,
Stroppiano Marina,
Dragani Alfredo,
Consonni Dario,
Barcellini Wilma,
Gaidano Gianluca,
Facchini Luca,
Specchia Giorgina,
Cappellini Maria Domenica
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12596
Subject(s) - medicine , enzyme replacement therapy , hematology , observational study , disease , dried blood spot , population , pediatrics , gaucher's disease , genetics , environmental health , biology
Gaucher disease ( GD ) is the most common lysosomal disorder resulting from deficient activity of the β‐glucosidase enzyme that causes accumulation of glucosylceramide in the macrophage–monocyte system. Notably, because of non‐specific symptoms and a lack of awareness, patients with GD experience long diagnostic delays. The aim of this study was to apply a diagnostic algorithm to identify GD type 1 among adults subjects referred to Italian haematology outpatient units because of splenomegaly and/or thrombocytopenia and, eventually, to estimate the prevalence of GD in this selected population. One hundred and ninety‐six subjects (61 females, 135 males; mean age 47.8 ± 18.2 years) have been enrolled in the study and tested for β‐glucosidase enzyme activity on dried blood spot ( DBS ). Seven of 196 patients have been diagnosed with GD , (5 females and 2 males) with mean age 31.8 ± 8.2 years, with a prevalence of 3.6% (with a prevalence of 3.6% (I95% CI 1.4–7.2; 1/28 patients) in this population. These results show that the use of an appropriate diagnostic algorithm and a simple diagnostic method, such as DBS , are important tools to facilitate the diagnosis of a rare disease even for not disease‐expert physicians.