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Establishment and characterization of a novel VEGF‐producing HHV‐8‐unrelated PEL‐like lymphoma cell line, OGU1
Author(s) -
Kawauchi Kiyotaka,
Ogasawara Toshie,
Aiba Motohiko,
Fujibayashi Mariko,
Sanaka Tsutomu,
Sakura Hiroshi,
Shibuya Masabumi
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12559
Subject(s) - primary effusion lymphoma , lymphoma , vascular endothelial growth factor , effusion , cancer research , pathology , medicine , biology , immunology , vegf receptors , surgery
Abstract Primary effusion lymphoma ( PEL ) is a rare B‐cell lymphoma subtype that is characterized by lymphomatous effusion without the presence of masses, and it typically occurs in human immunodeficiency virus ( HIV )‐infected individuals. Lymphoma cells are universally positive for human herpesvirus 8 ( HHV ‐8). Recently, a cavity‐based effusion lymphoma that is similar to PEL without HHV ‐8 infection, called HHV ‐8‐unrelated PEL ‐like lymphoma, has been reported in non‐ HIV ‐infected individuals. However, the pathophysiology of this lymphoma is largely undefined. We established a novel B‐cell line OGU 1 derived from a patient with HHV ‐8‐unrelated PEL ‐like lymphoma. Notably, OGU 1 cells produced vascular endothelial growth factor ( VEGF ) and expressed VEGF receptor 1, whose inhibitors retarded cell growth. Because VEGF acts as a vascular permeability and growth factor, it could play a role, at least in part, in the pathogenesis of this unique lymphoma. Thus, the OGU 1 cell line is useful for the investigation of HHV ‐8‐unrelated PEL ‐like lymphoma.