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Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O‐ CLL 1‐ GISL study
Author(s) -
Gentile Massimo,
Cutrona Giovanna,
Molica Stefano,
Ilariucci Fiorella,
Mauro Francesca R.,
Di Renzo Nicola,
Di Raimondo Francesco,
Vincelli Iolanda,
Todoerti Katia,
Matis Serena,
Musolino Caterina,
Fabris Sonia,
Lionetti Marta,
Levato Luciano,
Zupo Simona,
Angrilli Francesco,
Consoli Ugo,
Festini Gianluca,
Longo Giuseppe,
Cortelezzi Agostino,
Musto Pellegrino,
Federico Massimo,
Neri Antonino,
Ferrarini Manlio,
Morabito Fortunato
Publication year - 2016
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12545
Subject(s) - medicine , chronic lymphocytic leukemia , multivariate analysis , lymphocytosis , gastroenterology , post hoc analysis , stage (stratigraphy) , predictive value , leukemia , paleontology , biology
Abstract Objective We performed an external and multicentric validation of the predictive value of abdominal computed tomography ( aCT ) on time to first treatment ( TTFT ) in early stage chronic lymphocytic leukemia ( CLL ) patients. Methods aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O‐ CLL 1‐ GISL trial (clinicaltrial.gov ID : NCT 00917549). Results Fifty‐five patients showed an abnormal aCT . Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT ( P < 0.0001). At multivariate analysis, aCT ( P = 0.011), β ‐2 microglobulin ( P = 0.019), and CD 38 expression ( P = 0.047) correlated with TTFT . Following IWCLL 2008 criteria, 112 (61.9%) cases remained at Rai 0, while 69 (38.1%) satisfied the criteria of clinical monoclonal B‐cell lymphocytosis ( cMBL ). Reclassified Rai 0 patients with an abnormal aCT showed a significantly shorter TTFT than those with a normal aCT ( P < 0.0001). At multivariate analysis, only aCT ( P = 0.011) correlated with TTFT . Eleven cMBL cases (15.9%) showed an abnormal aCT and were reclassified as small lymphocytic lymphomas ( SLL ); nonetheless, TTFT was similar for cMBL s and SLLs. Conclusion Our results confirm the ability of the abnormal aCT to predict progression in early stage cases.