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TCL 1 expression predicts overall survival in patients with mantle cell lymphoma
Author(s) -
Shin SuJin,
Roh Jin,
Cha Hee Jeong,
Choi Yoo Duk,
Kim JinMan,
Min Soo Kee,
Kim Ji Eun,
Eom DaeWoon,
Lee Hojung,
Kim HyunJung,
Yoon Dok Hyun,
Suh Cheolwon,
Huh Jooryung
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12539
Subject(s) - mantle cell lymphoma , blastoid , tissue microarray , immunostaining , medicine , lymphoma , cancer research , clinical significance , pathology , staining , cell , immunohistochemistry , oncology , biology , genetics
Objectives Mantle cell lymphoma ( MCL ) has a heterogeneous clinical course. Although most cases show a poor prognosis, a minority has an indolent course. It is difficult to identify indolent MCL cases prospectively. T‐cell leukemia/lymphoma protein 1 ( TCL 1) is expressed by several B‐cell lymphomas, including MCL . This study examined the expression of TCL 1 and its prognostic relevance for MCL . Methods Clinical data for 162 patients with MCL were collected. Of these, 144 cases with available tissues for tissue microarray construction and immunostaining were included in the analysis. TCL 1 staining was quantified using the Nuclear Quant application with Pannoramic ™ Viewer v. 1.14. High TCL 1 expression was defined as moderate to strong nuclear and/or cytoplasmic staining in 40% or more of the cells. Results High TCL 1 expression was observed in 39 of 144 samples (27.1%). Patients with low TCL 1 expression were more likely to present with blastoid/pleomorphic morphology ( P = 0.010). Low TCL 1 expression was associated with significantly shorter overall survival ( OS , P = 0.006). Multivariate analysis identified low TCL 1 expression ( P = 0.003), high‐risk MIPI ( P = 0.027), and anemia ( P = 0.018) as adverse prognostic factors. Conclusions Our study suggests that TCL 1 expression profile may have a role in the prediction of overall outcome in patient with MCL and call for prospective studies.