Premium
Genetic susceptibility to diffuse large B‐cell lymphoma in a pooled study of three Eastern Asian populations
Author(s) -
Bassig Bryan A.,
Cerhan James R.,
Au WingYan,
Kim Hee Nam,
Sangrajrang Suleeporn,
Hu Wei,
Tse Jovic,
Berndt Sonja,
Zheng Tongzhang,
Zhang Heping,
Pornsopone Pattarapong,
Lee JeJung,
Kim HyeoungJoon,
Skibola Christine F.,
Vijai Joseph,
Burdette Laurie,
Yeager Meredith,
Brennan Paul,
Shin MinHo,
Liang Raymond,
Chanock Stephen,
Lan Qing,
Rothman Nathaniel
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12513
Subject(s) - genome wide association study , snp , diffuse large b cell lymphoma , genetic association , allele , oncology , population , medicine , single nucleotide polymorphism , lymphoma , biology , genetics , genotype , gene , environmental health
Objectives Diffuse large B‐cell lymphoma ( DLBCL ) is an aggressive subtype of non‐Hodgkin lymphoma ( NHL ) and is the most common NHL subtype diagnosed worldwide. The first large‐scale genome‐wide association study ( GWAS ) of DLBCL with over 4000 cases conducted among individuals of European ancestry recently identified five independent SNP s that achieved genome‐wide significance, and two SNP s that showed a suggestive association with DLBCL risk. Methods To evaluate whether Eastern Asians and individuals of European ancestry share similar genetic risk factors for this disease, we attempted to replicate these GWAS findings in a pooled series of 1124 DLBCL cases and 3596 controls from Hong Kong, South Korea, and Thailand. Results Three of the five genome‐wide significant SNP s from the DLBCL GWAS were significantly associated with DLBCL in our study population, including the top finding from the GWAS , EXOC 2 rs116446171, which achieved genome‐wide significance in our data (per allele OR = 2.04, 95% CI = 1.63–2.56; p trend = 3.9 × 10 −10 ). Additionally, we observed a significant association with PVT 1 rs13255292 (per allele OR = 1.34, 95% CI = 1.19–1.52; p trend = 2.1 × 10 −6 ), which was the second strongest finding in the GWAS , and with HLA ‐B rs2523607 (per allele OR = 3.05, 95% CI = 1.32–7.05; p trend = 0.009). Conclusions Our study, which provides the first evaluation in Eastern Asians of SNP s definitively associated with DLBCL risk in individuals of European ancestry, indicates that at least some of the genetic factors associated with risk of DLBCL are similar between these populations.