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Evaluation of bone involvement in patients with Gaucher disease: a semi‐quantitative magnetic resonance imaging method (using ROI estimation of bone lesion) as an alternative method to semi‐quantitative methods used so far
Author(s) -
Komninaka Veroniki,
Kolomodi Dionysia,
Christoulas Dimitrios,
Marinakis Theodoros,
Papatheodorou Athanasios,
Repa Konstantina,
Voskaridou Ersi,
Revenas Konstantinos,
Terpos Evangelos
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12504
Subject(s) - medicine , magnetic resonance imaging , nuclear medicine , region of interest , radiology , femur , n terminal telopeptide , pathology , alkaline phosphatase , chemistry , surgery , biochemistry , osteocalcin , enzyme
Abstract Objective The aim of this study was to evaluate bone involvement in patients with Gaucher disease ( GD ) and to propose a novel semi‐quantitative magnetic resonance imaging ( MRI ) staging. Methods MRI of the lumbar spine, femur, and tibia was performed in 24 patients with GD and 24 healthy controls. We also measured circulating levels of C‐C motif ligand‐3 ( CCL ‐3) chemokine, C‐telopeptide of collagen type‐1 ( CTX ), and tartrate‐resistant acid phosphatase isoform type‐b ( TRACP ‐5b). Results We used the following staging based on MRI data: stage I: region of interest ( ROI ) 1/2 of normal values and bone infiltration up to 30%; stage II: ROI 1/3 of normal values and bone infiltration from 30 to 60%; stage III: ROI 1/4 of normal values and bone infiltration from 60% to 80%; and stage IV: detection of epiphyseal infiltration, osteonecrosis and deformity regardless of the ROI 's values. All but two patients had abnormal MRI findings: 9 (37.5%), 6 (25%), 3 (12.5%), and 4 (16.7%) had stages I–IV, respectively. Patients with GD had elevated chitotriosidase, serum TRACP ‐5b, and CCL ‐3 levels ( P < 0.001). Conclusions We propose an easily reproducible semi‐quantitative scoring system and confirm that patients with GD have abnormal MRI bone findings and enhanced osteoclast activity possibly due to elevated CCL ‐3.