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Strategies for inhibitor treatment and costs in the short and long term: a critical evaluation of recent clinical studies
Author(s) -
Baghaipour Mohammad Reza,
Steen Carlsson Katarina
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12499
Subject(s) - medicine , haemophilia , intensive care medicine , recombinant factor viia , dose , surgery
One important complication of patients with severe haemophilia A is the formation of inhibitory antibodies to factor VIII ( FVIII ). Immune tolerance induction ( ITI ) is the treatment of choice for patients with inhibitors, but this approach is successful in about 60% of patients. Treatment of acute bleeding in patients with inhibitors is one of the greatest challenges in haemophilia management and is costly. Bypassing agents are the mainstay of treatment in these patients. The aims of this study were to review the most recent publications concerning the costs of inhibitor treatment. We conducted a literature review using PubMed which yielded 63 papers analysing the costs of inhibitor management of which 12 were suitable for our study. Four of eight studies supported the use of activated prothrombin complex concentrate (a PCC ) with lower costs, but the remaining four studies showed that recombinant factor VIIa (r FVII a) had a lower average treatment cost. Of four ITI studies, two supported lifelong cost‐effectiveness of ITI vs. bypassing agents and the remaining two papers showed a high cost of inhibitor treatment. Dosages, time between onset of bleeding and treatment, patient characteristics and the price of drugs are some of the important issues that should be considered for further studies.