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HAUSP compartmentalization in chronic myeloid leukemia
Author(s) -
Morotti Alessandro,
Panuzzo Cristina,
Crivellaro Sabrina,
Carrà Giovanna,
Guerrasio Angelo,
Saglio Giuseppe
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12422
Subject(s) - compartmentalization (fire protection) , myeloid leukemia , microbiology and biotechnology , biology , pten , cytoplasm , cancer research , signal transduction , biochemistry , pi3k/akt/mtor pathway , enzyme
PTEN plays an essential role in the pathogenesis of chronic myeloid leukemia. Recently, we have shown that BCR ‐ ABL promotes PTEN nuclear exclusion, through the modulation of HAUSP activity. Objectives Here, we investigate HAUSP cellular compartmentalization in primary CML samples. Results While in normal CD 34 positive cells HAUSP is expressed mostly in the nucleus, in CML CD 34 cells HAUSP is expressed both in the nuclear bodies and in the cytoplasm. Conclusions This observation suggests that HAUSP behaves as a shuttling protein in CML . It can bind to BCR ‐ ABL in the cytosol, where it is phosphorylated on tyrosine residues, and it maintains the proper compartmentalization in the nuclear bodies, where it acts as part of a PML network to regulate PTEN de‐ubiquitination.