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Severe radiotoxicity in an allogeneic transplant recipient with a heterozygous ATM mutation
Author(s) -
Ostendorf Benjamin N.,
Terwey Theis H.,
Hemmati Philipp G.,
Böhmer Dirk,
Pleyer Uwe,
Arnold Renate
Publication year - 2015
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12400
Subject(s) - medicine , ataxia telangiectasia , toxicity , mutation , radiation therapy , hematopoietic stem cell transplantation , oncology , haematopoiesis , telangiectasia , transplantation , stem cell , pathology , biology , gene , genetics , dna damage , dna
Patients receiving radiotherapy often experience toxicity of the skin and mucous membranes. While radiotherapy is a mainstay of myeloablative conditioning for allogeneic hematopoietic stem cell transplantation ( ASCT ), no risk factors for radiotoxicity have been identified in this setting. Here, we report on a patient with excessive radiation‐induced toxicity after ASCT who carried a heterozygous mutation in the Ataxia telangiectasia mutated ( ATM ) gene. This is the first case to suggest a genetic basis for increased radiotoxicity after myeloablative ASCT .