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Plasma cell myeloma with unusual morphology– A series of 6 cases
Author(s) -
Gupta Ruchi,
Hussain Naushad,
Rahman Khaliqur,
Nityanand Soniya
Publication year - 2014
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/ejh.12310
Subject(s) - immunophenotyping , plasma cell myeloma , pathology , bone marrow , plasma cell , immunofixation , plasma cell neoplasm , multiple myeloma , flow cytometry , differential diagnosis , plasmacytoma , biology , medicine , antibody , immunology , monoclonal , monoclonal antibody
Morphological variants of plasma cells have been described in cases of Plasma cell neoplasm. Presence of these atypical forms poses difficulty in morphological diagnosis and demands the use of ancillary techniques to ascertain the nature of these atypical cells. We hereby report a series of 6 such cases where the bone marrow examination showed plasma cells with atypical morphology, leading to varied differential diagnosis; however immunophenotyping by flow cytometry in adjunct to serum electrophoresis, immunofixation and free light chain assays confirmed the diagnosis.